IEFFICACY AND SAFETY OF FAECAL MICROBIOTA TRANSPLANTATION FOR ACTIVE PERIPHERAL PSORIATIC ARTHRITIS: A RANDOMIZED SHAM-CONTROLLED TRIAL
Abstract: OP0010
Authors: M. Skov Kragsnaes et al.
Key content:
Faecal microbiota transfer (FMT) has been proposed as a treatment option for extraintestinal inflammatory diseases. Results of a proof-of-concept, double-blind, parallel-group, sham- controlled superiority study are presented. 31 patients with active peripheral PsA despite MTX were randomized to receive one gastroscopic-guided FMT or sham transplantation into the duodenum. 30/31 completed the 26 weeks follow-up. Treatment failure was observed more frequently in the FMT group than in the sham treated patients (60% versus 19%, risk ratio 3.20 (95%CI 1.06–9.62, p = 0.018). No serious adverse events were observed.
Relevance:
The idea of modifying the gut microbiome in patients with psoriatic arthritis is intriguing given the association of inflammatory bowel diseases with spondyloarthropathies. Whether the use of several FMT´s would have resulted in improvement of peripheral arthritis that was not apparent after a single intervention might be discussed. As a rheumatologist I have to admit that I am not unhappy to discard FMT from my list of immunomodulatory treatments.
