FACTORS ASSOCIATED WITH REMISSION AT 5 YEARS OF FOLLOW-UP IN EARLY ONSET AXIAL SPONDYLOARTHRITIS: RESULTS FROM THE DESIR COHORT
Authors: L. Pina Vegas et al.
Remission is the goal for treatment of inflammatory rheumatic diseases. There is a lack of data on remission in axSpA and the factors, which are associated with reaching remission. This study using data from the French Desir cohort has analysed the proportion of patients in remission according to ASDAS-CRP (<1.3) after 5 years and compared their clinical characteristics with those patients not reaching remission. They found that the overall remission rate was 25%. 31% of non-TNF-inhibitor exposed patients were in remission but only 17% of the TNF-inhibitor exposed. Patients in remission were more frequently men, HLA-B27 positive, had a higher education and a lower BMI at 5yr follow up. Past history of arthritis and higher education were positively associated and low BASDAI, low BMI and low enthesitic index at baseline were negatively associated with remission at 5yrs.
This study shows astonishingly low remission rates after 5 years in patients with recent onset axSpA. Different baseline factors are associated with reaching remission, including overweight and the education level. It seems that treatment of axSpA is far from being optimal.